Islet Amyloid Development in a Mouse Strain Lacking Endogenous Islet Amyloid Polypeptide (IAPP) but Expressing Human IAPP

Myricetin Inhibits Islet Amyloid Polypeptide (IAPP) Aggregation and Rescues Living Mammalian Cells from IAPP Toxicity

The aggregation of the amyloidogenic polypeptide IAPP (Islet Amyloid Polypeptide, amylin) is believed to play a direct role in the death of pancreatic β-islet cells in type II diabetes. Preventing the initial aggregation event of IAPP is one strategy for slowing, and possibly preventing, the progression of this disease. Here, we investigate myricetin's potential as an inhibitor of IAPP aggregat...

Studies of Neuropeptides in Pancreatic Beta Cell Function with Special Emphasis on Islet Amyloid Polypeptide (IAPP)

Karlsson, E. 2001. Studies of Neuropeptides for Pancreatic Beta Cell Function with Special Emphasis on Islet Amyloid Polypeptide (IAPP). Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 980. 68 pp. Uppsala. ISBN 91-554-4890-9. The presence of protein amyloid in pancreas and its association to diabetes was first described 100 years ago...

Preventing the Aggregation of Islet Amyloid Polypeptide (IAPP) in Rat Insulinomas Using Novel Beta-Sheet Breakers

Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease

Oskarsson, M. 2015. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1158. 55 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9400-1. The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological fin...

Unfolding Novel Mechanisms of Polyphenol Flavonoids for Better Glycaemic Control: Targeting Pancreatic Islet Amyloid Polypeptide (IAPP)

Type 2 diabetes (T2D) is characterised by hyperglycaemia resulting from defective insulin secretion, insulin resistance, or both. The impact of over-nutrition and reduced physical activity, evidenced by the exponential rise in obesity and the prevalence of T2D, strongly supports the implementation of lifestyle modification programs. Accordingly, an increased consumption of fruits and plant-deri...